Title : ( N-tert-Butoxycarbonylation of amines using H3PW12O40 )
Authors: Akbar Heydari , Roohollah Kazem Shiroodi , Hossein Hamadi , Maryam Esfandyari , Mehrdad Pourayoubi ,
Full TextAbstract
The commercially available heteropoly acid H3PW12O40 (0.5 mol %) is a very efficient and environmentally benign catalyst for N-tert-butoxycarbonylation of amines (primary, secondary) with di-tert-butyl dicarbonate at room temperature in short reaction times (<10 min). No competitive side products such as isocyanates, ureas, N,N-di-tert-butoxycarbonyls, O-Boc and oxazolidinones were observed. Chiral a-amino alcohols and esters afforded the corresponding N-Boc derivatives chemoselectively in excellent yields.
Keywords
, N, tert, Butoxycarbonylation of amines using H3PW12O40
@article{paperid:1011596,
author = {Akbar Heydari and Roohollah Kazem Shiroodi and Hossein Hamadi and Maryam Esfandyari and Pourayoubi, Mehrdad},
title = {N-tert-Butoxycarbonylation of amines using H3PW12O40},
journal = {Tetrahedron Letters},
year = {2007},
volume = {48},
number = {33},
month = {August},
issn = {0040-4039},
pages = {5865--5868},
numpages = {3},
keywords = {N-tert-Butoxycarbonylation of amines using H3PW12O40},
}
%0 Journal Article
%T N-tert-Butoxycarbonylation of amines using H3PW12O40
%A Akbar Heydari
%A Roohollah Kazem Shiroodi
%A Hossein Hamadi
%A Maryam Esfandyari
%A Pourayoubi, Mehrdad
%J Tetrahedron Letters
%@ 0040-4039
%D 2007
