Background and Objective: Essential hypertension which affects 1 billion people worldwide is a multifactorial disorder and affected by both genetic and environmental factors. In human at about 14th week of pregnancy, sweat gland anlagen appear at uniform intervals along the apices of the epidermal ridges. Once the pores of sweat gland form on the ridge, they are fixed at that location. Considerable amount of researches have shown that pores do not disappear, move or spontaneously generate over time. The goal of the present study was to examine whether there is a relationship between the number of palmar sweat gland pores and hypertension condition. Materials and methods: By applying a digital microscope, the number of palmar sweat gland pores were counted in a circle area (12.5 –16.8 mm2) of certain anatomical regions (a, b, c triradials and fingers tip) in 75 hypertensive and 55 normotensive females. All patients had a familial background of hypertension and their average age was 60 years. Results: Statistical analysis of the data showed that the mean count of sweat gland\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s pores on fingers and b triradial in hypertensive group was significantly lower than normotensive subjects. Conclusion: The meaningful reduction of sweat gland\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s pores in hypertension condition can be used for the early monitoring and diagnosis of hypertension in susceptible persons, particularly among those with a familial background.

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