Title : ( Structure-activity study of phosphoramido acid esters as )
Authors: SAIED GHADIMI , ALI ASGHAR EBRAHIMI VALMOOZI , Mehrdad Pourayoubi , KEYVAN ASAD SAMANI ,
Full TextAbstract
Phosphoramido acid esters (CH3)2NP(O)X( p-OC6H4-CH3) (containing P-Cl (1), P-O (2), P-F (3), P-CN (5), and P-N (4,6) bonds, X for 2, 4 and 6 is OCH3, (C2H5)2Nand morpholin) have been synthesized to investigate the structure-activity study of AChE enzyme inhibition, through the parameters logP, d31P and IC50. After their characterization by 31P, 31P{1H}, 13C, 1H NMR, IR and mass spectroscopy, the parameters logP and d31P (31P chemical shift in NMR) were used to evaluated the lipophilicity and electronical properties. The ability of compounds to inhibit human AChE was predicted by PASS software (version 1.193), and experimentally evaluated by a modified Ellman’s assay.
Keywords
, Structure-activity study, phosphoramido acid ester, X-ray crystallography, acetylcholinesterase, IC50, lipophilicity, inhibition
@article{paperid:1011662,
author = {SAIED GHADIMI and ALI ASGHAR EBRAHIMI VALMOOZI and Pourayoubi, Mehrdad and KEYVAN ASAD SAMANI},
title = {Structure-activity study of phosphoramido acid esters as},
journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
year = {2008},
volume = {23},
number = {4},
month = {August},
issn = {1475-6366},
pages = {556--561},
numpages = {5},
keywords = {Structure-activity study; phosphoramido acid ester; X-ray crystallography; acetylcholinesterase; IC50; lipophilicity;
inhibition},
}
%0 Journal Article
%T Structure-activity study of phosphoramido acid esters as
%A SAIED GHADIMI
%A ALI ASGHAR EBRAHIMI VALMOOZI
%A Pourayoubi, Mehrdad
%A KEYVAN ASAD SAMANI
%J Journal of Enzyme Inhibition and Medicinal Chemistry
%@ 1475-6366
%D 2008
