Title : ( Corrigendum to ‘‘Design and synthesis of 4-methoxyphenylacetic acid estersras 15-lipoxygenase inhibitors and SAR comparative studies of them”[Bioorg. Med. Chem. 17 (2009) 2327 )
Authors: H. Sadeghian , Neda Attaran Kakhki , zeinab jafari , M. R. Saberi , Seyed Mohammad Seyedi , Hossein Eshghi , Mehdi Pordel , mahdi riazi ,
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Abstract
A group of 4-methoxyphenylacetic acid esters were designed, synthesized and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO) on the basis of eugenol and esteragol structures. Compounds 7d–e showed the best IC50 in SLO inhibition (IC50 = 3.8 and 1.9 lM, respectively). All compounds were docked in SLO active site and showed that carbonyl group of compounds is oriented toward the FeIII– OH moiety in the active site of enzyme and fixed by hydrogen bonding with hydroxyl group. It is assumed that lipophilic interaction of ligand–enzyme would be in charge of inhibiting the enzyme activity. The selectivity of the synthetic esters in inhibiting of 15-HLOb was also compared with 15-HLOa by molecular modeling and multiple alignment techniques.
Keywords
, Methylenation SLO Protein modeling Docking 15, HLO
@article{paperid:1013562,
author = {H. Sadeghian and Attaran Kakhki, Neda and Jafari, Zeinab and M. R. Saberi and Seyedi, Seyed Mohammad and Eshghi, Hossein and Pordel, Mehdi and Riazi, Mahdi},
title = {Corrigendum to ‘‘Design and synthesis of 4-methoxyphenylacetic acid estersras 15-lipoxygenase inhibitors and SAR comparative studies of them”[Bioorg. Med. Chem. 17 (2009) 2327},
journal = {Bioorganic & Medicinal Chemistry},
year = {2010},
volume = {18},
number = {1},
month = {January},
issn = {0968-0896},
pages = {462--462},
numpages = {0},
keywords = {Methylenation
SLO
Protein modeling
Docking
15-HLO},
}
%0 Journal Article
%T Corrigendum to ‘‘Design and synthesis of 4-methoxyphenylacetic acid estersras 15-lipoxygenase inhibitors and SAR comparative studies of them”[Bioorg. Med. Chem. 17 (2009) 2327
%A H. Sadeghian
%A Attaran Kakhki, Neda
%A Jafari, Zeinab
%A M. R. Saberi
%A Seyedi, Seyed Mohammad
%A Eshghi, Hossein
%A Pordel, Mehdi
%A Riazi, Mahdi
%J Bioorganic & Medicinal Chemistry
%@ 0968-0896
%D 2010
