Title : ( Synthesis and Biological Evaluation of Some New Thioether-Ester Crown Ethers )
Authors: Seyed Mohammad Seyedi , علی صادقیان , Hamid Sadeghian , aila hazrathoseyni , محمد صادقیان ,
Full TextAbstract
New thioether-ester crown ethers have been synthesized starting from oxalyl chloride and different β,β\'-dihydroxydithioethers. The synthesized compounds are screened for their antibacterial activity. Among the macrocyclic thioether-esters (5a-j), only 5,12-di[(allyloxy)methyl]-1,4-dioxa-7,10-dithiacyclododecane-2,3-dione (5e) and 5,12-di(isopropoxymethyl)-1,4-dioxa-7,10-dithiacyclododecane-2,3-dione (5f) were effective inhibitors against Staphilococcus aureus methicillin resistance and Pseudomanas aeruginosa with an MIC value of 525 and 265 μM. Structures of the synthesized compounds have been confirmed by 1H NMR, 13C NMR, and MS spectral studies.
Keywords
, Dihydroxydithioethers; Pseudomanas aeruginosa; Staphilococcus aureus; thioether, ester crown ethers
@article{paperid:1013670,
author = {Seyedi, Seyed Mohammad and علی صادقیان and Sadeghian, Hamid and Hazrathoseyni, Aila and محمد صادقیان},
title = {Synthesis and Biological Evaluation of Some New Thioether-Ester Crown Ethers},
journal = {Phosphorus, Sulfur, and Silicon and the Related Elements},
year = {2007},
volume = {182},
number = {2},
month = {February},
issn = {1042-6507},
pages = {265--272},
numpages = {7},
keywords = {Dihydroxydithioethers; Pseudomanas aeruginosa; Staphilococcus aureus; thioether-ester crown ethers},
}
%0 Journal Article
%T Synthesis and Biological Evaluation of Some New Thioether-Ester Crown Ethers
%A Seyedi, Seyed Mohammad
%A علی صادقیان
%A Sadeghian, Hamid
%A Hazrathoseyni, Aila
%A محمد صادقیان
%J Phosphorus, Sulfur, and Silicon and the Related Elements
%@ 1042-6507
%D 2007
