Title : ( Synchrotron X-Ray Powder Diffraction: Crystal Structure Determination of New Phosphodiesterase Enzymes Inhibitor )
Authors: Alireza Salimi , حمید رضا خواصی , مصطفی محمد پورامینی , حمید صادقیان , Hossein Eshtiagh Hosseini ,
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Abstract
Single crystal X-ray diffraction analysis is the usual way in the determination of structure of crystalline solids. Nowadays, however, many materials such as pharmaceutical compounds cannot be easily crystallized and exist only as powders. In these cases powder diffraction arises as an alternative. Synchrotron radiation is the most powerful source of X-rays currently available for powder diffraction experiments. In this study, we focused on structure determination of 6-(4-(4- methylpiperazin-1-yl)-4-oxobutoxy)-4-methylquinolin-2(1H)-one as a phosphodiesterase (PDE) enzymes inhibitor which improve cardiac contractility and may be used in congestive heart failure (CHF) which is a major cause of death in patients with heart disease.
Keywords
, Structure Determination, Synchrotron, Powder Diffraction, Enzymes Inhibitor.
@inproceedings{paperid:1017661,
author = {Salimi, Alireza and حمید رضا خواصی and مصطفی محمد پورامینی and حمید صادقیان and Eshtiagh Hosseini, Hossein},
title = {Synchrotron X-Ray Powder Diffraction: Crystal Structure Determination of New Phosphodiesterase Enzymes Inhibitor},
booktitle = {12th Iranian Inorganic Chemistry Conference},
year = {2010},
location = {Rasht, IRAN},
keywords = {Structure Determination; Synchrotron; Powder Diffraction; Enzymes Inhibitor.},
}
%0 Conference Proceedings
%T Synchrotron X-Ray Powder Diffraction: Crystal Structure Determination of New Phosphodiesterase Enzymes Inhibitor
%A Salimi, Alireza
%A حمید رضا خواصی
%A مصطفی محمد پورامینی
%A حمید صادقیان
%A Eshtiagh Hosseini, Hossein
%J 12th Iranian Inorganic Chemistry Conference
%D 2010
