Cytology and Genetics, ( ISI ), Volume (44), No (6), Year (2010-12) , Pages (339-344)

Title : ( Investigating the Effects of Vitreous Humour (Crude Extract) on Growth and Differentiation of Rat Mesenchymal Stem Cells (rMSCs) and Human NTERA2 Cells )

Authors: Alireza Jian Bagherpoor , Ahmad Reza Bahrami , Maryam Moghaddam Matin , Nasser Mahdavi SHahri , mohammad amin edalatmanesh ,

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Two main characteristics of all types of stem cells are their potency for differentiation and self renewal capacity. There is a lot of interest to find the conditions and factors, which govern these behaviours of stem cells. It is very well documented that retinoic acid (RA) reduces growth rate by induction of cell dif ferentiation in certain conditions and cell lines. On the other hand, hyaluronic acid (HA) is known for its growth induction on cultured cells. A natural source of HA, rabbit vitreous humour (VH), was previously shown to promote wound repair in model animals. In search for its possible mechanisms, VH extract was tested on the cultured mesenchymal stem cells and NTERA2 as human embryonal carcinoma cells in the presence of RA. Changes in some cellular and molecular markers (A2B5, 0ct4, Sox2) showed that VH and possibly HA interfere with differentiating effects of RA. Therefore, this reagent may affect cell proliferation and tissue regeneration by inhibition of cell differentiation.

Keywords

Vitreous
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@article{paperid:1019171,
author = {Jian Bagherpoor, Alireza and Bahrami, Ahmad Reza and Moghaddam Matin, Maryam and Mahdavi SHahri, Nasser and Edalatmanesh, Mohammad Amin},
title = {Investigating the Effects of Vitreous Humour (Crude Extract) on Growth and Differentiation of Rat Mesenchymal Stem Cells (rMSCs) and Human NTERA2 Cells},
journal = {Cytology and Genetics},
year = {2010},
volume = {44},
number = {6},
month = {December},
issn = {0095-4527},
pages = {339--344},
numpages = {5},
keywords = {Vitreous Humour},
}

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%0 Journal Article
%T Investigating the Effects of Vitreous Humour (Crude Extract) on Growth and Differentiation of Rat Mesenchymal Stem Cells (rMSCs) and Human NTERA2 Cells
%A Jian Bagherpoor, Alireza
%A Bahrami, Ahmad Reza
%A Moghaddam Matin, Maryam
%A Mahdavi SHahri, Nasser
%A Edalatmanesh, Mohammad Amin
%J Cytology and Genetics
%@ 0095-4527
%D 2010

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