Journal of Applied Toxicology, ( ISI ), Volume (1), No (1), Year (2010-1) , Pages (1-1)

Title : ( Removal of thallium by deferasirox in rats as biological model )

Authors: Amir SHokooh Saljooghi , S. Jamiladin Fatemi ,

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The present research aimed to characterize the potential efficiency of deferasirox in removing thallium after its administration for 30 days following two dose levels of 20 and 160 mM of thallium (III) chloride to maleWistar rats every day. After thallium administration some abnormal clinical signs such as red staining around the eyes, greenish mottling on the liver, weakness, loss of hair and weight, were observed in animals. Deferasirox was given orally to different groups of rats for a period of one week immediately after thallium administration. After chelation therapy, animals were killed by exsanguination from the abdominal aorta, and then thallium and iron concentrations in various tissues were determined by standard addition method. The chelation therapy results showed that deferasirox was able to remove thallium ions from the body and clinical symptoms were also reduced.


deferasirox; thallium toxicity; chelation therapy; rats
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author = {SHokooh Saljooghi, Amir and S. Jamiladin Fatemi},
title = {Removal of thallium by deferasirox in rats as biological model},
journal = {Journal of Applied Toxicology},
year = {2010},
volume = {1},
number = {1},
month = {January},
issn = {0260-437X},
pages = {1--1},
numpages = {0},
keywords = {deferasirox; thallium toxicity; chelation therapy; rats},


%0 Journal Article
%T Removal of thallium by deferasirox in rats as biological model
%A SHokooh Saljooghi, Amir
%A S. Jamiladin Fatemi
%J Journal of Applied Toxicology
%@ 0260-437X
%D 2010