The present research aimed to characterize the potential efficiency of Deferasirox in removing thallium after its administration for 30 days following two dose levels of 20 µM and 160 µM of thallium (III) chloride to male Wistar rats everyday. After thallium administration some abnormal clinical signs such as red staining around the eyes, greenish mottling on the liver, weakness, loss of hair and weight, were observed in animals. Deferasirox was given orally to different groups of rats for a period of one week immediately after thallium administration. After chelation therapy, animals were killed by exsanguinations from abdominal aorta, and then thallium and iron concentrations in various tissues were determined by standard addition method. The chelation therapy results showed Deferasirox was able to remove thallium ions from body and clinical symptoms were also reduced.

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