Journal of Sulfur Chemistry, ( ISI ), Volume (31), No (5), Year (2010-10) , Pages (415-526)

Title : ( New 2-pyridinealdehyde N4-hydroxyethyl thiosemicarbazone and their Cd(II) and Cu(II) complexes: synthesis, spectral, )

Authors: Reza Takjoo , Mohammad Hakimi , Mohammad Seyyedin , Mozhgan Abrishami ,

Citation: BibTeX | EndNote

N4-hydroxyethyl-pyridinealdehyde thiosemicarbazone (HL, 1) as a tridentate Schiff base has been synthesized by 1:1 reaction of S-methyl-3-((pyridyl)methyl) dithiocarbazate and 2-aminoethanol. Complexes [Cd(HL)2](NO3)2 (2), [Cd(HL)I2] (3), [Cd(HL)Cl2] (4), [Cu(HL)2](NO3)2 (5) and [Cu(HL)Cl2] (6) have been obtained and characterized by elemental analyses, molar conductivities, and spectroscopic studies. The ligand molecule binds the metal ion using pyridyl nitrogen, azomethine nitrogen and the sulfur atoms. The crystal structure analysis of 3 has been determined and showed to be a distorted square pyramidal geometry complex. The inter- and intramolecular interactions give rise to a supramolecular network. Compounds 2, 3, 5 and 6 were assayed for their bioactivities against selected pathogens. Copper(II) complexes 5 and 6 showed antimicrobial activities against Gram-positive (Bacillus anthracis) and Gram-negative (Pseudomonas aeruginosa and Yersinia pseudotuberculosis) bacteria, complexes 2–4 showed antimicrobial activities against Bacillus atrophaeus, while the ligand itself showed antimicrobial activities against Escherichia coli and Y. pseudotuberculosis.

Keywords

thiosemicarbazone; transition metal complex; antibacterial activity; crystal structure;
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@article{paperid:1021845,
author = {Takjoo, Reza and Mohammad Hakimi and Mohammad Seyyedin and Mozhgan Abrishami},
title = {New 2-pyridinealdehyde N4-hydroxyethyl thiosemicarbazone and their Cd(II) and Cu(II) complexes: synthesis, spectral,},
journal = {Journal of Sulfur Chemistry},
year = {2010},
volume = {31},
number = {5},
month = {October},
issn = {1741-5993},
pages = {415--526},
numpages = {111},
keywords = {thiosemicarbazone; transition metal complex; antibacterial activity; crystal structure; supramolecular},
}

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%0 Journal Article
%T New 2-pyridinealdehyde N4-hydroxyethyl thiosemicarbazone and their Cd(II) and Cu(II) complexes: synthesis, spectral,
%A Takjoo, Reza
%A Mohammad Hakimi
%A Mohammad Seyyedin
%A Mozhgan Abrishami
%J Journal of Sulfur Chemistry
%@ 1741-5993
%D 2010

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