The Optimal Characteristics for candidate cells to be used in cell therapy include their accessibility and success rate of isolation, proliferative capacity, ability to differentiate to various tissues, low immunogenicity, and last but not least, high potentials for targeted homing. Homing is the ability of cells in migration and engraftment to affected tissues. According to recent studies homing is closely related to the expression of chemokine receptors. Considering the role of chemokine receptors, comparison of the expression level of these receptors would help scientists to candidate and introduce better cell sources for cell therapies. In the present study, human MSCs were derived from bone marrow and adipose tissues and characterized by the expression of some cell surface antigens and also differentiation capacity. The expression of five chemokines: CCR1, CCR7, CXCR4, CXCR6 and CX3CR, which seems to be important in cell homing, were compared. Semi quantitative reverse transcription-polymerase chain reaction method was used to assess gene expression levels of these receptors. Our results indicate that expression of these receptors in human MSCs derived from adipose tissue was higher than MSCs from bone marrow. Therefore, MSCs from adipose tissue may show a better migration and homing capacity and they might be a better candidate for therapeutic purposes.

Keywords