Iranian Congress on Biology and Applications of Stem Cells , 2011-04-27

Title : ( Comparative Analysis of Chemokine Receptors Expression in Mesenchymal Stem Cells Derived From Human Bone Marrow and Adipose Tissue )

Authors: Hamid reza Bidkhori , Naghmeh Ahmadian Kia , Marzieh Ebrahimi , Maryam Moghaddam Matin , Naser Aghdami , zeinab neshati , Mahmood Rais Almohaddesin , Mahmoud Mahmoudi , Ahmad Reza Bahrami ,

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The Optimal Characteristics for candidate cells to be used in cell therapy include their accessibility and success rate of isolation, proliferative capacity, ability to differentiate to various tissues, low immunogenicity, and last but not least, high potentials for targeted homing. Homing is the ability of cells in migration and engraftment to affected tissues. According to recent studies homing is closely related to the expression of chemokine receptors. Considering the role of chemokine receptors, comparison of the expression level of these receptors would help scientists to candidate and introduce better cell sources for cell therapies. In the present study, human MSCs were derived from bone marrow and adipose tissues and characterized by the expression of some cell surface antigens and also differentiation capacity. The expression of five chemokines: CCR1, CCR7, CXCR4, CXCR6 and CX3CR, which seems to be important in cell homing, were compared. Semi quantitative reverse transcription-polymerase chain reaction method was used to assess gene expression levels of these receptors. Our results indicate that expression of these receptors in human MSCs derived from adipose tissue was higher than MSCs from bone marrow. Therefore, MSCs from adipose tissue may show a better migration and homing capacity and they might be a better candidate for therapeutic purposes.

Keywords

, Chemokine receptors, Mesenchymal stem cells, Adipose tissue, Bone
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@inproceedings{paperid:1022094,
author = {Bidkhori, Hamid Reza and Naghmeh Ahmadian Kia and Marzieh Ebrahimi and Moghaddam Matin, Maryam and Naser Aghdami and Neshati, Zeinab and Mahmood Rais Almohaddesin and Mahmoud Mahmoudi and Bahrami, Ahmad Reza},
title = {Comparative Analysis of Chemokine Receptors Expression in Mesenchymal Stem Cells Derived From Human Bone Marrow and Adipose Tissue},
booktitle = {Iranian Congress on Biology and Applications of Stem Cells},
year = {2011},
location = {مشهد, IRAN},
keywords = {Chemokine receptors; Mesenchymal stem cells; Adipose tissue; Bone marrow},
}

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%0 Conference Proceedings
%T Comparative Analysis of Chemokine Receptors Expression in Mesenchymal Stem Cells Derived From Human Bone Marrow and Adipose Tissue
%A Bidkhori, Hamid Reza
%A Naghmeh Ahmadian Kia
%A Marzieh Ebrahimi
%A Moghaddam Matin, Maryam
%A Naser Aghdami
%A Neshati, Zeinab
%A Mahmood Rais Almohaddesin
%A Mahmoud Mahmoudi
%A Bahrami, Ahmad Reza
%J Iranian Congress on Biology and Applications of Stem Cells
%D 2011

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