Journal of Molecular Neuroscience , ( ISI ), Volume (44), No (3), Year (2011-7) , Pages (178-185)

Title : ( Comparative Analysis of Chemokine Receptor's Expression in Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue )

Authors: Naghmeh Ahmadian kia , Ahmad Reza Bahrami , Marzieh Ebrahimi , Maryam Moghaddam Matin , zeinab neshati , Mahmood Rais Almohaddesin , Naser Aghdami , Hamid reza Bidkhori ,

Citation: BibTeX | EndNote

Mesenchymal stem cells (MSCs) are considered as promising candidates for new clinical trials of cell therapies. Bone marrow (BM) was the first source reported to contain MSCs; however, using it may be detrimental due to the highly invasive aspiration procedures. More recently, adipose tissue, attainable by a less invasive method, has been introduced as an alternative source of MSCs. So far, MSCs derived from these two sources have been compared in different characters; however, one of the main properties, i.e., the expression of chemokine receptors, has been ignored in these comparisons. In the present study, human MSCs were derived from bone marrow and adipose tissues and characterized by their expression of some cell surface antigens and also differentiation capacity. The expression of five selected chemokine receptors, which seems to be important in cell homing, was also compared. Semiquantitative reverse transcription-polymerase chain reaction method was used to assess gene expression levels of these chemokine receptors. Our results indicate that expression of these receptors in human MSCs, derived from adipose tissue, was higher than MSCs from bone marrow. Chemokine receptors and their ligands and adhesion molecules play an important role in tissuespecific homing of leukocytes and have also been implicated in trafficking of hematopoietic precursors into and through tissues. Therefore, MSCs from adipose tissue may show a better migration and homing capacity and they might be a better candidate for therapeutic purposes.

Keywords

Mesenchymal stem cells . Adipose tissue . Bone marrow . Chemokine
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1022229,
author = {Naghmeh Ahmadian Kia and Bahrami, Ahmad Reza and Marzieh Ebrahimi and Moghaddam Matin, Maryam and Neshati, Zeinab and Mahmood Rais Almohaddesin and Naser Aghdami and Bidkhori, Hamid Reza},
title = {Comparative Analysis of Chemokine Receptor's Expression in Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue},
journal = {Journal of Molecular Neuroscience },
year = {2011},
volume = {44},
number = {3},
month = {July},
issn = {0895-8696},
pages = {178--185},
numpages = {7},
keywords = {Mesenchymal stem cells . Adipose tissue . Bone marrow . Chemokine receptors},
}

[Download]

%0 Journal Article
%T Comparative Analysis of Chemokine Receptor's Expression in Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue
%A Naghmeh Ahmadian Kia
%A Bahrami, Ahmad Reza
%A Marzieh Ebrahimi
%A Moghaddam Matin, Maryam
%A Neshati, Zeinab
%A Mahmood Rais Almohaddesin
%A Naser Aghdami
%A Bidkhori, Hamid Reza
%J Journal of Molecular Neuroscience
%@ 0895-8696
%D 2011

[Download]