International Journal of Nanotechnology, ( ISI ), Volume (8), No (8), Year (2011-8) , Pages (700-711)

Title : ( Synthesis and characterisation of new designed protoporphyrin-stabilised gold nanoparticles for cancer cells nanotechnology-based targeting )

Authors: Hossein Eshghi , Neda Attaran Kakhki , Ameneh Sazgarnia , narges mirzayi , Ahmad Shanei ,

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Nanotechnology has entered the field of medicine in recent dacades and especially, in drug delivery systems, nanoparticles has shown an ability to improve pharmacokinetics, pharmacodynamics, efficacy and to reduce the toxicity of associated drugs. In this study, we have designed a new protoporphyrin-conjugated gold nanoparticle to selectively target and photo- or sonodynamic therapy of tumoural cells. In order to improve the cell uptake effect of protoporphyrin and their derivatives, gold nanoparticle was chosen as carrier. For this purpose, we used 6-mercapto-1-hexanol, as a bifunctional linker to react with protoporphyrin with an ester-linkage formation. Then, we conjugated the thiol-terminated protoporphyrin to the gold nanoparticles through a fast and single-phase system reaction with HAuCl4 in the presence of sodium borohydride. Finally, we evaluated the specific interaction between the protoporphyrin and gold nanoparticles by the elemental analysis, atomic absorption and UV-vis spectrum. Transmission electron microscopic images reveal the spherical gold nanoparticles formation with the average size about 7 nm. Therefore, we have synthesised gold nanoparticle conjugates with protoporphyrin which to be used as a biocompatible drug delivery system.

Keywords

cancer cell targeting; protoporphyrin; photodynamic therapy; gold nanoparticle;
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@article{paperid:1022240,
author = {Eshghi, Hossein and Attaran Kakhki, Neda and Ameneh Sazgarnia and Mirzayi, Narges and Ahmad Shanei},
title = {Synthesis and characterisation of new designed protoporphyrin-stabilised gold nanoparticles for cancer cells nanotechnology-based targeting},
journal = {International Journal of Nanotechnology},
year = {2011},
volume = {8},
number = {8},
month = {August},
issn = {1475-7435},
pages = {700--711},
numpages = {11},
keywords = {cancer cell targeting; protoporphyrin; photodynamic therapy; gold nanoparticle; nanotechnology.},
}

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%0 Journal Article
%T Synthesis and characterisation of new designed protoporphyrin-stabilised gold nanoparticles for cancer cells nanotechnology-based targeting
%A Eshghi, Hossein
%A Attaran Kakhki, Neda
%A Ameneh Sazgarnia
%A Mirzayi, Narges
%A Ahmad Shanei
%J International Journal of Nanotechnology
%@ 1475-7435
%D 2011

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