Title : ( THE EFFECTS OF SODIUM DODECYL SULFATE ON BOVINE CARBONIC ANHYDRASE STABILITy : MOLECULAR DYNAMICS SIMULATION STUDY )
Authors: Mohammad Reza Housaindokht , M. R. BOZORGMEHR , P. R. GOOLEY ,
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Abstract
All biological processes depend on proteins being stable and in the appropriate folded conformation. In this work, effects of sodium dodecyl sulfate (SDS) on bovine carbonic anhydrase (BCA) stability were studied by means of molecular dynamics simulation. Nine different concentrations of SDS were used. Secondary and tertiary structure changes were analyzed for BCA in the presence of these different concentrations of SDS. Mechanical stability of BCA was also considered. Results show that in the presence of 0.16% (w/w) SDS/water, changes in the BCA structure are different from those triggered by other SDS concentrations.
Keywords
, mechanical stability, molecular dynamics simulation, carbonic anhydrase, sodium dodecyl sulfate
@article{paperid:1022895,
author = {Housaindokht, Mohammad Reza and M. R. BOZORGMEHR and P. R. GOOLEY},
title = {THE EFFECTS OF SODIUM DODECYL SULFATE ON BOVINE CARBONIC ANHYDRASE STABILITy : MOLECULAR DYNAMICS SIMULATION STUDY},
journal = {Romanian Journal of Biochemistry},
year = {2011},
volume = {48},
number = {1},
month = {August},
issn = {1582-3318},
pages = {23--32},
numpages = {9},
keywords = {mechanical stability; molecular dynamics simulation; carbonic anhydrase; sodium
dodecyl sulfate},
}
%0 Journal Article
%T THE EFFECTS OF SODIUM DODECYL SULFATE ON BOVINE CARBONIC ANHYDRASE STABILITy : MOLECULAR DYNAMICS SIMULATION STUDY
%A Housaindokht, Mohammad Reza
%A M. R. BOZORGMEHR
%A P. R. GOOLEY
%J Romanian Journal of Biochemistry
%@ 1582-3318
%D 2011
