DNA binding is the critical step for DNA activity. In order to design effective chemotherapeutic agents and betteranticancer drugs, it is essential to explore the interactions of metalcomplexes with DNA [1-2].In this study, the interaction of DNA with a new cobalt complex with the formula of (Acr)4 [Co(Sal)3] was studied by means of UV–Visible absorption spectroscopy. The observed alterations in the absorbance due to changes of the complex indicate the occurrence of the interaction between the complex and DNA. The binding constant has been determined using absorption data[3], which found to be 4.69× 104M-1 in Tris–HCl buffer. Absorption study suggests that the cobalt complexinteracts with DNA most likely through a mode that involvesa stacking interaction between the aromatic chromophore and thebase pairs of DNA [4].

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