Abstract This current study designed to evaluate any possible changes in required doses and other cardiopulmonary findings after repeated propofol total intravenous anesthesia (TIVA) in dog. The study was conducted in 6 healthy sheepdogs, weight between 16.5 and 28 kg. Anaesthesia induced by 8 mg kg(-1) of propofol and maintained by continuous propofol (0.3 mg/kg/min) infusion in saline solution. All dogs received three times of propofol anaesthesia with the same protocol in a cross over design. As the animals in first, second and third time of anaesthesia allocated into groups 1, 2 and 3, respectively. Heart Rate (HR), rectal temperature (Temp), blood oxygen saturation (SpO2) by pulse oximetry and non invasive arterial blood pressures were measured. Times to the first swallowing attempt, ability to lift the head and standing were measured during recovery. The apnea was recorded in all animals but no significant difference was recorded between groups under study. Calculated doses of induction were sufficient for intubation of the animals. The average doses foe maintenance of anesthesia did not show any significant difference between groups under study. There were no significant differences found between groups in any comparable parameter. Despite of longer recovery time in group three, there were no significant differences between the Groups in different recovery times. Repeated propofol anesthesia did not improve resistance and respiratory changes in this species. However, some effects on blood pressure may happen without any effect on heart rate.

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