9th Iran Biophysical Chemistry Conference , 2010-02-24

Title : ( The interaction mode between DNA and salen-Co(III) N,N’-dipyridoxyl (1,4-butanediamine) Shiff-base complex )

Authors: Zahra Mashhadi Khoshkhoo , Mohammad Reza Housaindokht , Razieh Jalal , Hossein Eshtiagh Hosseini , sayyed hamid mir tabatabae , Masoud Mirzaei Shahrabi ,

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In this work, we studied the interaction of new salen-co(III) of N,N\\\'-dipyridoxyl (1,4-butanediamine) Schiff-base complex with DNA by melthing temperature, fluorescence spectrometry and gel electrophoresis techniques. This salen-Co(III) complex shows increase in melting temperature when bound to native calf thymus-DNA (CTDNA). The intersection point of the binding isotherm indicated a binding site size of 3 bp per bound complex molecule in Tris–HCl buffer. Upon adding the new salen-Co(III), the electrophoretic mobility of pTZ57R DNA plasmid becomes slower for both super coiled and open circular forms without any structural changes in DNA. The experimental results showed that the salen-Co(III) complex bound to DNA by intercalative mode.In this work, we studied the interaction of new salen-co(III) of N,N

Keywords

, Schiff bases, anticancer, melting temperature, structural
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@inproceedings{paperid:1024417,
author = {Mashhadi Khoshkhoo, Zahra and Housaindokht, Mohammad Reza and Jalal, Razieh and Eshtiagh Hosseini, Hossein and Mir Tabatabae, Sayyed Hamid and Mirzaei Shahrabi, Masoud},
title = {The interaction mode between DNA and salen-Co(III) N,N’-dipyridoxyl (1,4-butanediamine) Shiff-base complex},
booktitle = {9th Iran Biophysical Chemistry Conference},
year = {2010},
location = {تهران, IRAN},
keywords = {Schiff bases; anticancer; melting temperature; structural change.},
}

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%0 Conference Proceedings
%T The interaction mode between DNA and salen-Co(III) N,N’-dipyridoxyl (1,4-butanediamine) Shiff-base complex
%A Mashhadi Khoshkhoo, Zahra
%A Housaindokht, Mohammad Reza
%A Jalal, Razieh
%A Eshtiagh Hosseini, Hossein
%A Mir Tabatabae, Sayyed Hamid
%A Mirzaei Shahrabi, Masoud
%J 9th Iran Biophysical Chemistry Conference
%D 2010

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