Nano dendrimers are a branch of nano particle group that are interested in variety of fields [1]. Because of their ability to confinement of molecules in their branches or ability to connection with the functional surface groups, these particles are able to use as a targeted delivery of many particles especially for drugs [2]. In this study, hydroxyl derivative of nano-PAMAM dendrimers were synthesized and evaluated to bind to the drugs containing carboxylic acid moiety. According to the reports, shelf life of the drug effect for dendrimers with hydroxyl terminal groups is very high [3]. Also in lower generation of dendrimers, in addition to their less toxicity [4], dramatic increase in the solubility of hydrophobic species was also observed [5]. Nano dendrimer compound with hydroxyl terminated groups were prepared from the reaction of synthesized PAMAM dendrimers with tris hydroxymethyl amino methane in DMSO. The structure of the desired product was confirmed by spectral and microanalytical data. Consequently, the resulted product was reacted with acyl chloride derivative of aspirin. The results of multiple tests were indicated that the successful conjugation was performed and the complexes of Nano dendrimer to drugs were obtained.

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