Biochemistry and Cell Biology, ( ISI ), Volume (90), No (2), Year (2012-4) , Pages (115-123)

Title : ( New windows to enhance direct reprogramming of somatic cells towards induced pluripotent stem cells )

Authors: saeideh nakhaei rad , Ahmad Reza Bahrami , mahdi mirahmadi , Maryam Moghaddam Matin ,

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Induced pluripotent stem cells are generated by direct reprogramming of somatic cells with the introduction of defined transcription factors or other means. Clinical applications of induced pluripotent stem cells are the latest of stem cell therapy approaches due to overcoming problems associated with insufficient cells from conventional sources and immune rejections. In practice, this is restricted by 4 major barriers including the use of genetic manipulations for delivering the reprogramming factors, low efficiency of this process, slow kinetics of the direct reprogramming, and potential for tumor development. Here, we review the latest achievements in improving reprogramming efficiency by alternative strategies. These alternatives mainly involve the replacement of genetic reprogramming factors with small molecules or other factors.

Keywords

, reprogramming, iPS cells, stem cell factors, small
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@article{paperid:1027360,
author = {Nakhaei Rad, Saeideh and Bahrami, Ahmad Reza and Mirahmadi, Mahdi and Moghaddam Matin, Maryam},
title = {New windows to enhance direct reprogramming of somatic cells towards induced pluripotent stem cells},
journal = {Biochemistry and Cell Biology},
year = {2012},
volume = {90},
number = {2},
month = {April},
issn = {0829-8211},
pages = {115--123},
numpages = {8},
keywords = {reprogramming; iPS cells; stem cell factors; small molecules},
}

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%0 Journal Article
%T New windows to enhance direct reprogramming of somatic cells towards induced pluripotent stem cells
%A Nakhaei Rad, Saeideh
%A Bahrami, Ahmad Reza
%A Mirahmadi, Mahdi
%A Moghaddam Matin, Maryam
%J Biochemistry and Cell Biology
%@ 0829-8211
%D 2012

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