Title : ( Direct catalyst-free multicomponent Mannich reactions for synthesis of new bis(β- aminocarbonyl) compounds )
Authors: Hossein Eshghi , Mohammad Rahimizadeh , fatemeh eshkil ,
دانلود فایل برای اعضای دانشگاهAccess to full-text not allowed by authors
Abstract
A highly diastereoselective catalyst-free multicomponent Manich reaction between cyclohexanone, aromatic aldehydes and diamines is described. The product mixtures were found to contain only bis(β-aminocarbonyl) product in each case, which were isolated and purified by precipitation and crystallization. Reactions were occurred in 62-78% yields and good diasteroselectivity. The best selectivity was obtained where there are weak EWGs and ERGs on aldehyde. The reactivity decreases when strong EWGs and or ERGs are present on aldehyde. Aromatic diamines are more suitable than aliphatic diamines in this reaction. In these cases only corresponding imines are obtained in high yields.
Keywords
, Bis(β, aminocarbonyl) compounds; Mannich reaction; combinatorial chemistry; catalyst, free
@inproceedings{paperid:1028295,
author = {Eshghi, Hossein and Rahimizadeh, Mohammad and Eshkil, Fatemeh},
title = {Direct catalyst-free multicomponent Mannich reactions for synthesis of new bis(β- aminocarbonyl) compounds},
booktitle = {1st National Conference on Multi-Component Reactions},
year = {2012},
location = {کرمان, IRAN},
keywords = {Bis(β-aminocarbonyl) compounds; Mannich reaction; combinatorial chemistry; catalyst-free},
}
%0 Conference Proceedings
%T Direct catalyst-free multicomponent Mannich reactions for synthesis of new bis(β- aminocarbonyl) compounds
%A Eshghi, Hossein
%A Rahimizadeh, Mohammad
%A Eshkil, Fatemeh
%J 1st National Conference on Multi-Component Reactions
%D 2012
