Basic and Clinical Neuroscience, Volume (3), No (4), Year (2012-8) , Pages (60-67)

Title : ( Effects of Infantile Repeated Hyperglycemia on Behavioral Alterations in Adult male and female Rats )

Authors: Malihe Moghadami , Ali Moghimi , Razieh Jalal , Emad Ahangar , Morteza Behnam Rassouli , Nasser Mahdavi SHahri ,

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Anxiety symptoms have been reported to be present in many patients with diabetes mellitus. However, little is known about the effects of hyperglycemia in critical periods of development of the central nervous system. We assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. Our findings showed significant hypo activity, reduced locomotive/exploratory activities, increased fear related behaviors, and anxiety state between hyperglycemic and control adult males and the same differences between females. And so, no significant behavioral alterations between male and female animals were observed. This study determined that repeated increments in daily blood sugar levels in newborns may affect neuronal functions and provide behavior abnormalities in adults.

Keywords

, Anxiety, Elevated plus maze, Exploratory, Hyperglycemia, Locomotive, Open
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@article{paperid:1029121,
author = {Moghadami, Malihe and Moghimi, Ali and Jalal, Razieh and Emad Ahangar and Behnam Rassouli, Morteza and Mahdavi SHahri, Nasser},
title = {Effects of Infantile Repeated Hyperglycemia on Behavioral Alterations in Adult male and female Rats},
journal = {Basic and Clinical Neuroscience},
year = {2012},
volume = {3},
number = {4},
month = {August},
issn = {2008-126x},
pages = {60--67},
numpages = {7},
keywords = {Anxiety; Elevated plus maze; Exploratory; Hyperglycemia; Locomotive; Open field},
}

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%0 Journal Article
%T Effects of Infantile Repeated Hyperglycemia on Behavioral Alterations in Adult male and female Rats
%A Moghadami, Malihe
%A Moghimi, Ali
%A Jalal, Razieh
%A Emad Ahangar
%A Behnam Rassouli, Morteza
%A Mahdavi SHahri, Nasser
%J Basic and Clinical Neuroscience
%@ 2008-126x
%D 2012

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