Tetrahedron, ( ISI ), Volume (68), No (38), Year (2012-8) , Pages (8046-8051)
Title : ( Diastereoselective synthesis of 5-iminooxazolines and their subsequent transformation to α,α-disubstituted dipeptide esters: a formal [4+1] cycloaddition reaction of cyclohexyl isocyanide and Z-alkyl-α-benzoyl amino-acrylates )
Authors: Abbas Ali Esmaeili , Shima Shahmansouri , Azizollah Habibi , Ali Reza Fakhari ,
دانلود فایل برای اعضای دانشگاهAccess to full-text not allowed by authors
Abstract
A novel atom economical diastereoselective synthesis of 5-iminooxazolines and their subsequent transformation to α,α-disubstituted dipeptide esters is described. Heating a mixture of cyclohexyl isocyanide and Z-α-benzoyl amino-acrylic acid alkyl esters under solvent-free conditions, afforded 5-iminooxazolines, which, upon specifications provided α,α-disubstituted dipeptide esters in good yield.
