Xanthene derivatives are very important heterocyclic compounds and have been widely used as dyes fluorescent materials for visualization of biomolecules and laser technologies due to their useful spectroscopic properties. [1] This compounds have also been investigated for agricultural bactericidal activity, [2] photodynamic therapy, [3] anti-inflammatory effects, [4] antiviral activity, [5] and for antagonism of the paralyzing action of zoxazolamine.[6] Because of the remarkable properties, their synthesis has been considered by researchers. Due to the widespread use of xanthene derivatives, various methods for their synthesis have been reported. In this article we have reported synthesis of new and the most commonly used of xanthene derivatives. For this purpose, the xanthydrol was reacted with different derivatives of 2-naphthol in acidic conditions.

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