Iranian Journal of Veterinary Surgery, Volume (5), No (1), Year (2010-4) , Pages (9-18)

Title : ( 1433η Protein is Detectable in Blood Serum and Fetlock Joint Synovial Fluid of High Performance Horses )

Authors: Kamran Sardari , Claudia Chavez-Munoz , Ruhangiz Tabatabaee Kilani , Neil Thomas McKenzie , Aziz Ghahary ,

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Objective: To investigate whether 14-3-3 eta protein is detectable in synovial fluid and blood serum of high performance horses and to study whether any significant correlation between this and matrix metalloproteinase 1 and 3 in horse synovial fluid. Design: Clinical study. Animals: Eleven standard breed horses (seven high performances and four controls). Procedures: Blood serum and fetlock synovial fluid of seven high performance and four control horses were subjected to western blot for detection of 14-3-3 eta, gama, matrix metalloproteinase 1 and 3 proteins. Results: High level of 14-3-3 eta protein was detected in synovial fluid of high performance horses compare to those of control (P<0.05). 14-3-3 gama protein was detectable in synovial fluid and significant differences was found between high performance and control horses (P<0.05). The level of matrix metalloproteinase 1 and 3 were significantly increased in samples of high performance horses relative to of that control (p<0.05). The results showed that 14-3-3 eta protein was significantly increased in serum samples of high performance horses relative to of that control (P<0.05). Conclusions and Clinical Relevance: 14-3-3 eta isoform can be readily detected in synovial fluid and blood serum of high performance horses and presence of this protein has significant effect on the levels of matrix metalloproteinase 1 and 3 in synovial fluid. As the high performance horses are always prone to joint diseases, this protein might be use as an early diagnostic tool in some joint inflammatory conditions.

Keywords

, horse, 14-3-3 eta, matrix metalloproteinase, joint,
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@article{paperid:1029647,
author = {Sardari, Kamran and Claudia Chavez-Munoz and Ruhangiz Tabatabaee Kilani and Neil Thomas McKenzie and Aziz Ghahary},
title = {1433η Protein is Detectable in Blood Serum and Fetlock Joint Synovial Fluid of High Performance Horses},
journal = {Iranian Journal of Veterinary Surgery},
year = {2010},
volume = {5},
number = {1},
month = {April},
issn = {2008-3033},
pages = {9--18},
numpages = {9},
keywords = {horse; 14-3-3 eta; matrix metalloproteinase; joint; arthritis.},
}

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%0 Journal Article
%T 1433η Protein is Detectable in Blood Serum and Fetlock Joint Synovial Fluid of High Performance Horses
%A Sardari, Kamran
%A Claudia Chavez-Munoz
%A Ruhangiz Tabatabaee Kilani
%A Neil Thomas McKenzie
%A Aziz Ghahary
%J Iranian Journal of Veterinary Surgery
%@ 2008-3033
%D 2010

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