Introduction: Comprehensive treatment model is one of the valid approaches in treatment of children with autism spectrum disorders. Holistic multidimensional treatment model (Hojati model) is designed based on existing research literature in the area of comprehensive treatment models to treat such children. Objective: The purpose of this study was to investigate the effectiveness of holistic multidimensional treatment model (Hojati model) in improvement of clinical symptoms in children with autism spectrum disorders. Methods: The research design of the current study was quasi-experimental. The research sample included 150 subjects with autism spectrum disorders who were selected by available sampling, and assigned in to three treatment groups randomly. In the first, second and third groups, subjects were treated for one, two and three years, respectively. These children initially were evaluated by a highly qualified child and adolescent psychiatrist and received diagnosis based on Autism Diagnostic Interview Revised (ADIR) and Autism Diagnostic Observation Schedule (ADOS) and were referred to Noor-e-Hidayat Center, a specialized center for autistic children. In this study, to evaluate the severity of symptoms in autistic children, autism rating scale was used. Data analysis of this study was performed by analysis of variance test with repeated measures. Results: The results suggested that holistic multidimensional treatment model has been effective in treatment of children with autism spectrum disorders in all the three groups (p <0/05). On the other hand, severity of symptoms of autism spectrum disorders

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