Introduction: Parent of children with autism face challenges placing them at risk for high level of stress and other negative psychological outcomes. Involvement of parents in implementing intervention strategies designed to help their children can reduce these negative outcomes. Objectives: The purpose of the present study was to investigate the impact of Parent Education and Skill Training Program (PESTP) on reducing stress of mothers of preschool children with autism. Methods: This semi-experimental study was conducted with pretest, posttest and follow-up design, using control group. Samples of the study were 21 mothers of preschool children with autism (aged 3-7 years) in Mashhad who were randomly selected and allocated to experimental and control groups. Participants in experimental group received eleven sessions of training with the PESTP. All participants completed Parenting Stress Index (PSI) at pre and post-training and then a70- day follow-up. Data obtained from this study was analyzed by repeated measures analysis of variance. Results: The results showed that training with the PESTP reduced maternal stress after 70-day follow-up (p<0/05).Conclusion: This finding confirms the effectiveness of parents’ training in reducing stress of mothers of children with autism.

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