Journal Chromatography B, ( ISI ), Volume (908), No (21), Year (2012-10) , Pages (67-75)

Title : ( Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol–gel fiber coating )

Authors: Ali Sarafraz Yazdi , Amirhassan Amiri , Glamhossein Ronagi , Hossein Eshtiagh Hosseini ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote

A new rapid, simple and effective cleanup procedure is demonstrated for the determination of ibuprofen, naproxen and diclofenac in urine samples by using hollow-fiber liquid membrane-protected solid-phase microextraction (HFLM-SPME) based on sol–gel technique and gas chromatography–flame ionization detector (GC–FID). In this technique, a sol–gel coated fiber was protected with a length of porous polypropylene hollow fiber membrane which was filled with water-immiscible organic phase. Subsequently the whole device was immersed into urine sample for extraction. Poly(ethylene glycol) (PEG) grafted onto multi-walled carbon nanotubes (PEG-g-MWCNTs) was used as extraction phase to prepare the sol–gel SPME fiber. Important parameters influencing the extraction efficiency such as desorption temperature and time, organic solvent, extraction temperature and time, pH, stirring speed and salt effect were investigated and optimized. Under the optimal conditions, the method detection limits (S/N = 3) were in the range of 0.03–0.07 ng mL−1 and the limits of quantification (S/N = 10) between 0.08 and 0.15 ng mL−1. Relative standard deviations for intra-day and inter-day precisions were 4.8–9.0% and 4.9–8.1%, respectively. Subsequently, the method was successfully applied to human urine fractions after administration of ibuprofen, naproxen and diclofenac. © 2012 Elsevier B.V. All rights reserved

Keywords

, Hollow, fiber liquid membrane, protected solid, phase microextraction Multi, walled carbon nanotubes Sol–gel technology Non, steroidal anti, inflammatory drugs Urine
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1030479,
author = {Sarafraz Yazdi, Ali and Amirhassan Amiri and Ronagi, Glamhossein and Eshtiagh Hosseini, Hossein},
title = {Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol–gel fiber coating},
journal = {Journal Chromatography B},
year = {2012},
volume = {908},
number = {21},
month = {October},
issn = {1570-0232},
pages = {67--75},
numpages = {8},
keywords = {Hollow-fiber liquid membrane-protected solid-phase microextraction Multi-walled carbon nanotubes Sol–gel technology Non-steroidal anti-inflammatory drugs Urine samples},
}

[Download]

%0 Journal Article
%T Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol–gel fiber coating
%A Sarafraz Yazdi, Ali
%A Amirhassan Amiri
%A Ronagi, Glamhossein
%A Eshtiagh Hosseini, Hossein
%J Journal Chromatography B
%@ 1570-0232
%D 2012

[Download]