Introduction: Neurological disorders due to anesthesia in the immature animal models rise lots of questions about the overall human health regard to general anesthesia performance. Compounds which block the NMDA receptors or enhance effects of GABA in the critical period of growth, two days before the birth to day 14th after that, affect brain development and synaptogenesis. The aim of this study was to investigate the effects of repeated anesthesia induced by thiopental on memory retrieval. Methods: Neonates of Westar rat with 5 days old were divided into 3 groups (n=7) of control (no treatment), sham (saline) and Thiopental (30 mg/kg), i.p. injections were performed for 5 constitutive days, anesthesia was continued for 4-5 hours per day in Thiopental group. Infants in the day 19th, and parallel groups after maturation were subjected to Morris Water Maze for 4 constitutive days. Probe test performed at the 5th by which time spent in target quadrant was evaluated as memory recall criteria. Results: There were not significant differences before and after puberty in memory retention criteria between animals in control, sham and animals which experienced repeated thiopental induced infant anesthesia. Discussion: The results of our previous work showed that thiopental repeated anesthesia in infants can affect the learning process after maturation, but the results of the present study showed that the mentioned infant treatment had no effect on memory recall even after maturation, difference in the results may be related to the difference in the neuronal pathways underlying the learning progress and memory retention which needs to clarify more.

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