Chromatographia, ( ISI ), Volume (66), No (8), Year (2007-4) , Pages (613-617)

Title : Directly suspended droplet microextraction and analysis of amitriptyline and nortriptyline by GC ( Directly Suspended Droplet Microextraction and Analysis of Amitriptyline and Nortriptyline by GC )

Authors: Ali Sarafraz Yazdi , Samaneh Raouf Yazdinezhad , Zarrin Eshaghi ,

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Directly Suspended Droplet Microextraction (DSDME) was used for the determination of two tricyclic antidepressant drugs (TCAs), amitriptyline and nortriptyline. In this technique, an aqueous sample is agitated with a stirring bar, creating a mild vortex at the center of the vial. A droplet of an immiscible organic solvent is placed at the bottom of the vortex. After 20 min a portion of the organic droplet is withdrawn with a syringe and injected into the GC. Experimental conditions, such as the extraction solvent, extraction time, solvent volume, stirring rate, pH and salt addition were optimized. In order to evaluate the practical application of the method, relative standard deviations, linearity range and limits of detection were calculated. Typical enrichment factors were 167 and 179 for amitriptyline and nortriptyline, respectively. The method was applied to the determination of these drugs in urine samples.

Keywords

Gas chromatography Directly Suspended Droplet Microextraction Amitriptyline and nortriptyline
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@article{paperid:103111,
author = {Sarafraz Yazdi, Ali and Raouf Yazdinezhad, Samaneh and Eshaghi, Zarrin},
title = {Directly suspended droplet microextraction and analysis of amitriptyline and nortriptyline by GC},
journal = {Chromatographia},
year = {2007},
volume = {66},
number = {8},
month = {April},
issn = {0009-5893},
pages = {613--617},
numpages = {4},
keywords = {Gas chromatography Directly Suspended Droplet Microextraction Amitriptyline and nortriptyline Antidepressants},
}

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%0 Journal Article
%T Directly suspended droplet microextraction and analysis of amitriptyline and nortriptyline by GC
%A Sarafraz Yazdi, Ali
%A Raouf Yazdinezhad, Samaneh
%A Eshaghi, Zarrin
%J Chromatographia
%@ 0009-5893
%D 2007

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