Title : ( Synthesis of Nanovectors Based on Functionalization Of Single wall Carbon Nanotubes (SWNT) with Polyethylenimine and Evaluation of their Transfection Efficiency in Gene Delivery )
Authors: azadeh hashem nia , M. Ramezani , Mohammad Rahimizadeh , Hossein Eshghi , Kh. Abnoos ,
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Abstract
Carbon nanotubes (CNTs) have found their uses in the biological sciences at molecular and cellular levels. Studies interfacing CNTs with biological molecules indicate that such interfaces can be established while the functions of biological molecules are preserved. In our study we used functionalization procedures to improve the solubility and biocompatibility of SWNT. PEI ( poly ethylene imine) have been extensively searched for its binding ability to plasmid due to positive surface charge of its porotonated amine groups in biologic pH and different vectors are synthesized by modifying PEI molecules to improve its viability . By attaching PEI to the surface of SWNT, synthesized vectors will be able to bind plasmid efficiently and internalize the cell without causing allergic reactions and can be used as delivery vehicles for gene delivery purpose.
Keywords
, Single wall Carbon Nanotube, Functionalization, Poly Ethylene Imine, Gene Delivery
@inproceedings{paperid:1031830,
author = {Hashem Nia, Azadeh and M. Ramezani and Rahimizadeh, Mohammad and Eshghi, Hossein and Kh. Abnoos},
title = {Synthesis of Nanovectors Based on Functionalization Of Single wall Carbon Nanotubes (SWNT) with Polyethylenimine and Evaluation of their Transfection Efficiency in Gene Delivery},
booktitle = {4th International Conference on Nanostructures (ICNS4)},
year = {2012},
location = {IRAN},
keywords = {Single wall Carbon Nanotube; Functionalization; Poly Ethylene Imine; Gene Delivery},
}
%0 Conference Proceedings
%T Synthesis of Nanovectors Based on Functionalization Of Single wall Carbon Nanotubes (SWNT) with Polyethylenimine and Evaluation of their Transfection Efficiency in Gene Delivery
%A Hashem Nia, Azadeh
%A M. Ramezani
%A Rahimizadeh, Mohammad
%A Eshghi, Hossein
%A Kh. Abnoos
%J 4th International Conference on Nanostructures (ICNS4)
%D 2012
