Photodiagnosis and Photodynamic Therapy, ( ISI ), Volume (10), No (3), Year (2013-9) , Pages (304-3012)

Title : ( Protoporphyrin IX - Gold Nanoparticle Conjugates as an Efficient Photosensitizer in Cervical Cancer Therapy )

Authors: Hossein Eshghi , Ameneh Sazgarnia , Mohammad Rahimizadeh , Neda Attaran Kakhki , Mehdi Bakavoli , Samaneh Soudmand ,

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Protoporphyrin IX (PpIX) conjugated gold nanoparticle (GNP) was synthesized, characterized, and used for the delivery of a hydrophobic photosensitizer to a cervical cancer cell line. The GNP conjugates have an average diameter of 7 nm. The conjugated GNPs were made by a single coupling reaction. Protoporphyrin absorbs radiation at 630 nm and catalytically produces the reactive oxygen species in high efficiency. These properties indicate that PpIX-GNP conjugates could be used as a photosensitizer in photodynamic therapy (PDT) through the formulation of singlet oxygen. The conjugates were tested on Hela cells. PDT efficacy of the system was evaluated with the MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. The effect of photon-induced toxicity was assesed by comparing it with control experiments. Our findings suggest that the PpIX-GNP conjugate is an excellent carrier for the delivery of surface bound hydrophobic protoporphyrin molecule into the cell which makes PpIX- GNP conjugates potential candidates for PDT.

Keywords

, Protoporphyrin IX, Gold nanoparticles, Photodynamic therapy, HeLa
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@article{paperid:1032395,
author = {Eshghi, Hossein and Ameneh Sazgarnia and Rahimizadeh, Mohammad and Attaran Kakhki, Neda and Bakavoli, Mehdi and Samaneh Soudmand},
title = {Protoporphyrin IX - Gold Nanoparticle Conjugates as an Efficient Photosensitizer in Cervical Cancer Therapy},
journal = {Photodiagnosis and Photodynamic Therapy},
year = {2013},
volume = {10},
number = {3},
month = {September},
issn = {1572-1000},
pages = {304--3012},
numpages = {2708},
keywords = {Protoporphyrin IX; Gold nanoparticles; Photodynamic therapy; HeLa cells},
}

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%0 Journal Article
%T Protoporphyrin IX - Gold Nanoparticle Conjugates as an Efficient Photosensitizer in Cervical Cancer Therapy
%A Eshghi, Hossein
%A Ameneh Sazgarnia
%A Rahimizadeh, Mohammad
%A Attaran Kakhki, Neda
%A Bakavoli, Mehdi
%A Samaneh Soudmand
%J Photodiagnosis and Photodynamic Therapy
%@ 1572-1000
%D 2013

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