Basic and Clinical Neuroscience, Volume (4), No (1), Year (2013-2) , Pages (31-35)

Title : ( The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat s Electroencephalogram Characteristics )

Authors: Ali Moghimi , Samaneh Mollazadeh , Fatemeh Behnam Rassouli , Reza Shiee , Mohammad Ali Khalilzade ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote

Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy.

Keywords

, Ciprofloxacin, Absence
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1033059,
author = {Moghimi, Ali and Samaneh Mollazadeh and Behnam Rassouli, Fatemeh and Reza Shiee and Mohammad Ali Khalilzade},
title = {The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat s Electroencephalogram Characteristics},
journal = {Basic and Clinical Neuroscience},
year = {2013},
volume = {4},
number = {1},
month = {February},
issn = {2008-126x},
pages = {31--35},
numpages = {4},
keywords = {Ciprofloxacin; Absence Epilepsy; Wag/Rij; EEG.},
}

[Download]

%0 Journal Article
%T The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat s Electroencephalogram Characteristics
%A Moghimi, Ali
%A Samaneh Mollazadeh
%A Behnam Rassouli, Fatemeh
%A Reza Shiee
%A Mohammad Ali Khalilzade
%J Basic and Clinical Neuroscience
%@ 2008-126x
%D 2013

[Download]