12th Iranian Inorganic Chemistry Conference , 2010-09-15

Title : ( Synchrotron X-Ray Powder Diffraction:‎ Crystal Structure Determination of New Phosphodiesterase Enzymes Inhibitor )

Authors: Alireza Salimi , Hossein Eshtiagh Hosseini , H. R. Khavasi , M. Mohammadpour Amini , H. Sadeghian ,

Citation: BibTeX | EndNote

Single crystal X-ray diffraction analysis is the usual way in the determination of structure of crystalline solids. ‎Nowadays, however, many materials such as pharmaceutical compounds cannot be easily crystallized and exist ‎only as powders. In these cases powder diffraction arises as an alternative. Synchrotron radiation is the most ‎powerful source of X-rays currently available for powder diffraction experiments. Narrow peaks, accurate peak ‎positions and excellent signal to background ratios means that synchrotron data are ideal for structure solution ‎‎[1]. ‎ In this study, we focused on structure determination of 6-(4-(4-methylpiperazin-1-yl)-4-oxobutoxy)-4-‎methylquinolin-2(1H)-one as a phosphodiesterase (PDE) enzymes inhibitor which improve cardiac contractility ‎and may be used in congestive heart failure (CHF) which is a major cause of death in patients with heart disease ‎‎[2].‎

Keywords

, Structure Determination, Synchrotron, Powder Diffraction, Enzymes
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@inproceedings{paperid:1033537,
author = {Salimi, Alireza and Eshtiagh Hosseini, Hossein and H. R. Khavasi and M. Mohammadpour Amini and H. Sadeghian},
title = {Synchrotron X-Ray Powder Diffraction:‎ Crystal Structure Determination of New Phosphodiesterase Enzymes Inhibitor},
booktitle = {12th Iranian Inorganic Chemistry Conference},
year = {2010},
location = {رشت, IRAN},
keywords = {Structure Determination; Synchrotron; Powder Diffraction; Enzymes Inhibitor},
}

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%0 Conference Proceedings
%T Synchrotron X-Ray Powder Diffraction:‎ Crystal Structure Determination of New Phosphodiesterase Enzymes Inhibitor
%A Salimi, Alireza
%A Eshtiagh Hosseini, Hossein
%A H. R. Khavasi
%A M. Mohammadpour Amini
%A H. Sadeghian
%J 12th Iranian Inorganic Chemistry Conference
%D 2010

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