Objectives: Goat pox is an important viral disease in Middle East. Its mortality is often less than 10%, case fatality rate of about 100% is reported in some young animals. Although the disease is endemic in Iran, but the importance of this report is two points, one is the affection of saanen goats as a non- native goat in Iran and the other is the occurrence of the disease after vaccination by the available vaccine in Iran.The final aim of this report is giving some knowledge about the application of TC goragan strain goat pox vaccine in non-native to Materials & Methods: In summer, 1389, taken the visit of two heads of saanen goat in a farm in mashhad, the goat pox were diagnosed. The goats were vaccinated by goat pox vaccine 17 days ago. In clinical examinations, the findings were fever, respiratory distress with harsh lung sound, rhinitis, conjunctivitis, nasal mucopurulent discharge. Macules and papules with necrotic points in their center were observed in different parts of the body including on the muzzle, around the ears, abdomen, tail and udders. Many nodules with hair loss were touched in subcutaneous tissue at all over the skin from head to tail. Results & Conclusion: The manifestation of goat pox is more sever in non-native goats than native goats. Respiratory and visceral lesions and also bacterial secondary infections have important role in mortality. Abortions, mastitis, skin condemnation, loss of animal production and exports are the most important economic losses. According to available information, this is probably the first report of goat pox in saanen goat in Iran after vaccination with TC -gorgan strain vaccine. In this paper, in addition to confirm the recommendation listed in the brochure of goat pox vaccine that is not to use the vaccine for non- native goats, the uncommon nodular form of goat pox (stone pox) were presented as a clinical feature in the affected goats .Also, the methods of treatment of the affected goats and its results, the latest knowledge about the control, prevention and treatment of goat pox is presented. It should be noted, that no using of the vaccine from that time till now, and no report of the disease in that farm were reported.

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