Background: A wide range of environmental and genetical factors are involved in infertility including chemotherapeutic drugs, antibiotics, toxins, pollution, radiation, stress and lack of vitamins. Chemotherapeutic dosage of cisplatin impairs spermatogenesis and ultimately causes a zoospermia and infertility in some men.This study investigates the short-term effects of cisplatin, which is widely used for chemotherapy, on the testes histology and spermatogenesis in mice. Materials & Methods: Male mice aging 8-12 weeks(25-30 gr) were divided into two groups: (1) control, (2) Cisplatin which ip injected for five days as 2.5 mg/kg, 7days after, the end of treatment, body and testicular weights and histopathological changes were evaluated. Results: The body weights of group 2 was signifigantly reduced (p<0.05), also the microscopic observations indicated that the diameter of seminiferous tubules and epithelial thickness was diminished (p<0.05), on the other hand, the diameter of tubuls lumen was increased. Conclusions: We can conclude that this drug cannot differentiate between cancerous and the normal cells. So mitotic cells such as spermatogonum also can affect with it. Cisplatin can affect spermatogenesis and spermatogenic cells possibly via free radicals production.

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