Background: The cytotoxic effects of chemotherapy agents and its effect on fertility, is very imprortant for medical applications. Vitamin C is a well known antioxidant that can ameliorate oxidative stress related to testicular impairments in animal tissues. It can scavenge free radicals and it can return back the other antioxidants such as vitamin E and urate in a cycle. The purpose of the present study was to evaluate the effect of vitamin C on cisplatin treated mice testes. Material & Methods: Male mice aging 8-12 weeks and 25-30 mg weights were divided into three groups: (1) control, (2) Cisplatin 2.5 mg/kg body weight with ip injection), (3) cisplatin +Vitamin C, 20mg/Kg b.w using gavage.7days later, body and testicular weights, and histopathological changes were evaluated. Results: Body weight of the group 2 was signifigantly reduced (p<0.05), also the microscopic observations were indicated that the diameter of seminiferous tubules and epithelial thickness was diminished (p<0.05) on the other hand, diameter of the tubules lumen increased in this group. In group 3 vitamin C improved the destroying effects of cisplatin on seminiferous parameters. Conclusions: In Conclusions, the present study found that the supplementation of vitamin C could ameliorate cisplatin testicular disorders may be because it can scavenge free radicals which were produced by cisplatin.

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