This article deals with the effect of semantic features of native lexical items on Persian speaking learners of English in translation and has been arranged in four parts. In the first part the semantics and different kinds of errors including interlingual errors has been introduced briefly. In the second part, some experiments carried out in high school and university to observe the effect of semantics features of native lexical items on Persian speaking learners of English has been presented. In the third part the results of these experiments has been analyzed and in last part the reasons why most of Persian speaking learners of English make lexico-semantics errors and some solutions are mentioned.

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