Title : ( Piperazine immobilized on silica gel as an inexpensive and recyclable catalyst for synthesis of 2-amino-2H-chromenes )
Authors: neda golary , Mohammad Rahimizadeh , Mehdi Bakavoli ,
Full TextAbstract
2-Amino-2H-chromenes and their derivatives are of considerable interest as they posses as a wide range of biological properties, such as spasmolytic, diuretic, anticoagulant, anticancer and antianaphylactic activity [1]. Modified silica matrices have been widely applied in the last three decades in various fields such as catalysis, HPLC,GC, separation of toxic metals traces from waste water, and so on [2].The present investigation demonstrate the use of piperazineimmobilized on silica gel as an efficient basic catalyst in the synthesis of 2-amino-2H-chromenes[3,4]. We have studied the three component synthesis of 2-amino-2H-chromenes via one pot reaction of aldehydes, malonitrile and α- or β-naphtol using piperazineimmobilized on silica gel as an available, green and inexpensive catalyst with good yields. The protocolpresented here has the merits of environmentally benign,simple operation, convenient work-up and good yields.Furthermore, the catalyst can be easily recovered andreused for at least five times without significant loss of its activity
Keywords
, 2-Amino-2H-chromenes and their derivatives are of considerable interest as they posses as a wide range of biological properties, such as spasmolytic, diuretic, anticoagulant, anticancer and antianaphylactic activity [1]. Modified silica matrices have been widely applied in the last three decades in
@inproceedings{paperid:1035438,
author = {Golary, Neda and Rahimizadeh, Mohammad and Bakavoli, Mehdi},
title = {Piperazine immobilized on silica gel as an inexpensive and recyclable catalyst for synthesis of 2-amino-2H-chromenes},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {2-Amino-2H-chromenes and their derivatives are of considerable interest as they posses as a wide range of biological properties; such as spasmolytic; diuretic; anticoagulant; anticancer and antianaphylactic activity [1]. Modified silica matrices have been widely applied in the last three decades in various fields such as catalysis; HPLC;GC; separation of toxic metals traces from waste water; and so on [2].The present investigation demonstrate the use of piperazineimmobilized on silica gel as an efficient basic catalyst in the synthesis of 2-amino-2H-chromenes[3;4].
We have studied the three component synthesis of 2-amino-2H-chromenes via one pot reaction of aldehydes; malonitrile and α- or β-naphtol using piperazineimmobilized on silica gel as an available; green and inexpensive catalyst with good yields. The protocolpresented here has the merits of environmentally benign;simple operation; convenient work-up and good yields.Furthermore; the catalyst can be easily recovered andreused for at least five times without significant loss of its activity},
}
%0 Conference Proceedings
%T Piperazine immobilized on silica gel as an inexpensive and recyclable catalyst for synthesis of 2-amino-2H-chromenes
%A Golary, Neda
%A Rahimizadeh, Mohammad
%A Bakavoli, Mehdi
%J 20th Iranian Seminar of Organic Chemistry
%D 2013
