Objective Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders that often persist into adulthood. Studies suggest that ADHD is common among prison populations. Moreover, ADHD is associated with a high percentage of comorbid psychiatric disorders, mainly anxiety and depression, personality disorder, and substance abuse. The aim of the present study was to explore the effects of a computerized working memory training on reducing comorbid psychiatric symptoms among prison inmates with attention deficit/hyperactivity disorder. Method Through randomized sampling method, 20 adult male prison inmates (22 to 41 years old) in Gorgan State Prison (North of Iran) who had formerly received ADHD diagnosis were recruited on a voluntary basis. Participants were randomly assigned to experimental group who received a computerized working memory training program for 25 sessions through 5 weeks, and passive control group. To measure the severity of comorbid psychiatric symptoms from before to after the training, the participants completed Beck Anxiety Inventory (BAI), Beck Depression Inventory-2 (BDI-II) and Millon Clinical Multiaxial Inventory (MCMI-III). Results The experimental participants reported significant change (p<0.05) on BAI, BDI, PTSD, and bipolar disorder symptoms. But no significant change was reported on personality disorders symptoms (p>0.05). Conclusion The results suggest that working memory training can be an effective intervention for reducing some comorbid psychiatric symptoms in male prison inmates with ADHD. In addition, the data supports the feasibility of offering working memory training in a correctional setting

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