Title : ( Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils )
Authors: Mehdi Bakavoli , Hossein Eshghi , Ali Shiri , toktam afrough , javad tajabadi ,
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Abstract
The sodium salts of the conj ugated bases of uracils und ergo high ly che moselective O4-monoalkylation when treated with various alkyl halides in dry DMF, w h ile the use of methyl iodide results in N1þ N3dimethylation. Theoretical evalua tions of the chemo- and regioselectivity along with X-ray crystallographic data are presented.
Keywords
, 6-Methyl uracil, HMDS, O-Alkylation, GIAO 13C NMR
@article{paperid:1035658,
author = {Bakavoli, Mehdi and Eshghi, Hossein and Shiri, Ali and Afrough, Toktam and Tajabadi, Javad},
title = {Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils},
journal = {Tetrahedron},
year = {2013},
volume = {69},
number = {39},
month = {August},
issn = {0040-4020},
pages = {8470--8476},
numpages = {6},
keywords = {6-Methyl uracil; HMDS; O-Alkylation; GIAO 13C NMR},
}
%0 Journal Article
%T Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils
%A Bakavoli, Mehdi
%A Eshghi, Hossein
%A Shiri, Ali
%A Afrough, Toktam
%A Tajabadi, Javad
%J Tetrahedron
%@ 0040-4020
%D 2013
