16th Iranian Chemistry Congress , 2013-09-07

Title : ( Synthesis of Novel Imidazo[2,1-b]pyrimido[5,4-e][1,3,4]thiadiazines )

Authors: mina myandarhoey , Mehdi Bakavoli , Ali Shiri ,

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The imidazole moiety is present in a wide range of naturally occurring molecules 1 .Imidazoleshave important roles in biological systems and are categorized as fungicides, herbicides 2 , plant growth regulators 3 . and therapeutic agents 4 . Thiadiazine is incorporated into many important biological and medicinal compounds. This ring exhibit properties such as antiviral, antiprotozoal, antiparastic, antidiabetic, antiherpes 5,6 . Due to their wide range of biological, industrial, and synthetic applications, in this study, we reportthe synthesis of new derivatives of imidazo[2,1-b]pyrimido[5,4-e][1,3,4]thiadiazine 3(a-e) from the reaction of 5-boromo-2,4-dichloro-6-methyl pyrimidine (1) and 1Himidazole-2-thiol (2) in the presence of Et3N at room temperature. Substitution of chlorine atom at position 2 with various secondary amines in boiling ethanol, followed by heterocyclization of the resulting products with NaNH2 in CH3CN furnished the 3 desired products 3(a-e) (Scheme 1).


, Imidazo[2, 1-b]pyrimido[5, 4-e][1, 3, 4]thiadiazines
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author = {Myandarhoey, Mina and Bakavoli, Mehdi and Shiri, Ali},
title = {Synthesis of Novel Imidazo[2,1-b]pyrimido[5,4-e][1,3,4]thiadiazines},
booktitle = {16th Iranian Chemistry Congress},
year = {2013},
location = {یزد, IRAN},
keywords = {Imidazo[2;1-b]pyrimido[5;4-e][1;3;4]thiadiazines},


%0 Conference Proceedings
%T Synthesis of Novel Imidazo[2,1-b]pyrimido[5,4-e][1,3,4]thiadiazines
%A Myandarhoey, Mina
%A Bakavoli, Mehdi
%A Shiri, Ali
%J 16th Iranian Chemistry Congress
%D 2013