16th Iranian Chemistry Congress , 2013-09-07

Title : ( Fe(HSO4)3 as an Efficient Catalyst for the synthesis of N- (benzothiazole-2-yl)-1-(Aryl)-O,O-diethyl-α- aminophosphonates )

Authors: Hossein Eshghi , mehdi mirzaei , Mohammad Rahimizadeh ,

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In recent years, considerable interest has been focused on the synthesis ofα- aminophosphonates, because they are considered to be structural analogues of the corresponding α-aminoacids. In these connections, important utilitiesofα - aminophosphonates as anti cancer ,antibiotics and pharmacologic agentsare well documented [1-2]. Herein,a three-component synthesis of α-aminophosphonate is described from a reactionbetween aldehydes, 2-aminobenzothiazole, and diethyl phosphite in the presence of FHS as a catalyst under solvent-free conditions for the generation of the particular α- aminophosphonates. These products have two potentially biologically active parts, α- aminophosphonate and benzothiazole. This method offers advantages such as short reaction times, good yields, solvent-free conditions, and easy workup with the green aspects by avoiding toxic catalysts and solvents.The α-aminophosphonates have been characterized by elemental analysis, IR and NMR (1H, 13C and 31P) spectra (Scheme 1).

Keywords

, Fe(HSO4)3, N- (benzothiazole-2-yl)-1-(Aryl)-O, O-diethyl-α-
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@inproceedings{paperid:1036146,
author = {Eshghi, Hossein and Mirzaei, Mehdi and Rahimizadeh, Mohammad},
title = {Fe(HSO4)3 as an Efficient Catalyst for the synthesis of N- (benzothiazole-2-yl)-1-(Aryl)-O,O-diethyl-α- aminophosphonates},
booktitle = {16th Iranian Chemistry Congress},
year = {2013},
location = {یزد, IRAN},
keywords = {Fe(HSO4)3; N- (benzothiazole-2-yl)-1-(Aryl)-O;O-diethyl-α- aminophosphonates},
}

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%0 Conference Proceedings
%T Fe(HSO4)3 as an Efficient Catalyst for the synthesis of N- (benzothiazole-2-yl)-1-(Aryl)-O,O-diethyl-α- aminophosphonates
%A Eshghi, Hossein
%A Mirzaei, Mehdi
%A Rahimizadeh, Mohammad
%J 16th Iranian Chemistry Congress
%D 2013

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