Squamous cell carcinoma (SCC) is a tumour consisting of squamous epithelial cells. This tumour is common in horses, cows, cats and dogs, but relatively uncommon in sheep, goats and pigs. In this study, we discuss gross, radiological and histopathological features of an oral SCC in a female sheep. A 3-year-old ewe with a progressive mass located in the intraoral cavity and with a history of reduced appetite, weight loss, salivation and halitosis was referred to the veterinary clinic. At clinical examination, amass was located in the floor of the mouth, its surfaces showed signs of ulceration and haemorrhage. Lateral radiograph of the mandible region near the tumour showed bone destructive changes. Biopsy specimen was taken and histopathologic examination showed moderately differentiated oral SCC.

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