Research on Chemical Intermediates, ( ISI ), Volume (41), No (6), Year (2015-6) , Pages (3649-3658)

Title : ( PPh3-catalyzed Mannich reaction: a facile one-pot synthesis of b-amino carbonyl compounds under solvent-free conditions at room temperature )

Authors: javad abedini torghabeh , Hossein Eshghi , Mehdi Bakavoli , Mohammad Rahimizadeh ,

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Abstract

PPh3 was used as an efficient catalyst for the one-pot three-component Mannich reactions of acetophenone with different aromatic amines and aromatic aldehydes under solvent-free conditions at room temperature. This method provides a novel and improved method for preparing b-amino carbonyl compounds in the absence of acidic catalyst in excellent yield. Little catalyst loading, easy accessibility of the catalyst, mild conditions, and simple work-up procedure are the main features of this protocol.

Keywords

, Mannich reaction,  One-pot,  Triphenylphosphine,  Solvent free,  b-Amino carbonyl