Arabian Journal of Chemistry, ( ISI ), Volume (7), No (6), Year (2014-11) , Pages (1000-1002)

Title : ( Investigation of regioselectivity on the reaction of 5-bromo-2,4-dichloro-6-methylpyrimidine with ammonia )

Authors: Abdolhassan Doulah , Hossein Eshtiagh Hosseini , Masoud Mirzaei Shahrabi , Mohsen Nikpour , Ali Fazlara , Alireza Salimi ,

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Abstract

Regioselective displacement reaction of ammonia with 5-bromo-2,4-dichloro-6-methylpyrimidine was studied by X-ray crystallography analysis and showed the formation of 5-bromo-2-chloro-6-methylpyrimidin-4-amine as a main product. Reaction of the latter compound with secondary amines in boiling ethanol afforded 4-amino-5-bromo-2-substituted aminopyrimidines. The synthesized compound in this paper crystallized in the monoclinic crystal system space group P21/n. In the title cocrystal, 5-bromo-2-chloro-6-methylpyrimidin-4-amine·3H2O, the asymmetric unit contains one crystallographically independent 5-bromo-2-chloro-6-methylpyrimidin-4-amine and three crystallization of water molecules. The typical intramolecular O−H⋯N as well as O−H⋯O hydrogen bond is observed in the crystalline network of the title compound. It is interesting to point out that the crystal structure is further stabilized by O−H⋯O hydrogen bonds created by (H2O)∞ clusters.

Keywords

, 5-Bromo-2, 4-dichloro-6-methylpyrimidine; 5-Bromo-2-chloro-6-methylpyrimidin-4-amine; X-ray crystallography