Objective: This short communication describes a case of osteoarthritis and systemic infection caused by Candida albicans in a 2-year-old Mynah (Acridotherestristis). Candida albicans is a major agents of mucous membrane mycosis in humans and animals, with systemic and deep infections especially in immunocompromised hosts. Materials and Methods:The bird has history of abdominal hernia surgery with depression, cachexia, lethargy, distension of foot joints and granuloma-like masses at the surface of foot skin was presented. Articular fluid obtained and sent for mycological and bacterial analysis. In spite of topical and systemic treatments, the bird was presented again with a touchable firm mass in the abdomen which confirmed by radiography and ultrasonography. Symptomatic and antifungal therapy continued but clinical signs deteriorated and the animal euthanized and necropsized. Gross examination revealed liver lesions indicating of fatty liver symptoms, renal lesions as pale focal necrosis and intestinal hemorrhage.Tissue samples of kidney, testis, liver, spleen, duodenum, jejunum, ileum and toes were preserved in 10% neutral buffered formalin and were sent to the Pathology Laboratory. Tissue sections were fixed in 10% neutral buffered formalin, processed by routine histological methods and stained with Hematoxylin and eosin (H & E). On microscopic examination, in addition to severe congestion; many microorganism colonies were seen in toes’ skin, liver and kidney. The organism was recognized by masses of entangled pseudohyphae and budding yeast-like organisms in liver and kidney. Severe hemorrhage, vasculitis with invasion of fungal organisms into the vessels' wall associated with infiltration of inflammatory cells was observed. The inflammatory cells were primarily heterophils, macrophages, and lymphocytes. To definitive diagnosis of the fungi, Period Acid Schiff (PAS) and Acid-fast aststainings carried out on the liver, kidney and toe skin. Results and Discussion: According to histopathologic, bacterial and mycologic results final diagnosis was systemic candidiasis and osteoarthritis caused by Candida albicans

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