21st Iranian Seminar of Organic Chemistry , 2014-03-13

Title : ( Synthesis of new derivatives of pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine )

Authors: toktam akaberi , Mohammad Rahimizadeh , ,

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Abstract

Pyrimidine derivatives and heterocyclic annulated pyrimidines continue to attract great interest due to the wide variety of interesting biological activities observed for these compounds, such as anticancer [1], antiviral [2], antitumor [3], and anti­inflammatory activities [4]. In this study, 5­bromo­2­chloro­4­hydrazino­6­methyl pyrimidine (1) was synthesized according to our previous method.[5] The treatment of this compound with 2,6­ dicholoropyridazine (2) in pyridine gave quantitatively the desired heterocyclized pyridazino[6,1­ c]pyrimido[5,4­e][1,2,4]triazine derivative as a novel heterocyclic system. Eventually, the reaction of it with various secondary amines obtained new derivatives of pyridazino[6,1­c]pyrimido[5,4­ e][1,2,4]triazine 3(a­e).

Keywords

, pyridazino[6, 1-c]pyrimido[5, 4-e][1, 2, 4]triazine
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@inproceedings{paperid:1040783,
author = {Akaberi, Toktam and Rahimizadeh, Mohammad and , },
title = {Synthesis of new derivatives of pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine},
booktitle = {21st Iranian Seminar of Organic Chemistry},
year = {2014},
location = {ایلام, IRAN},
keywords = {pyridazino[6;1-c]pyrimido[5;4-e][1;2;4]triazine},
}

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%0 Conference Proceedings
%T Synthesis of new derivatives of pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine
%A Akaberi, Toktam
%A Rahimizadeh, Mohammad
%A ,
%J 21st Iranian Seminar of Organic Chemistry
%D 2014

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