Title : ( Synthesis of new derivatives of pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine )
Authors: toktam akaberi , Mohammad Rahimizadeh , Ali Shiri ,Access to full-text not allowed by authors
Abstract
Pyrimidine derivatives and heterocyclic annulated pyrimidines continue to attract great interest due to the wide variety of interesting biological activities observed for these compounds, such as anticancer [1], antiviral [2], antitumor [3], and antiinflammatory activities [4]. In this study, 5bromo2chloro4hydrazino6methyl pyrimidine (1) was synthesized according to our previous method.[5] The treatment of this compound with 2,6 dicholoropyridazine (2) in pyridine gave quantitatively the desired heterocyclized pyridazino[6,1 c]pyrimido[5,4e][1,2,4]triazine derivative as a novel heterocyclic system. Eventually, the reaction of it with various secondary amines obtained new derivatives of pyridazino[6,1c]pyrimido[5,4 e][1,2,4]triazine 3(ae).
Keywords
, pyridazino[6, 1-c]pyrimido[5, 4-e][1, 2, 4]triazine@inproceedings{paperid:1040783,
author = {Akaberi, Toktam and Rahimizadeh, Mohammad and Shiri, Ali},
title = {Synthesis of new derivatives of pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine},
booktitle = {21st Iranian Seminar of Organic Chemistry},
year = {2014},
location = {ایلام, IRAN},
keywords = {pyridazino[6;1-c]pyrimido[5;4-e][1;2;4]triazine},
}
%0 Conference Proceedings
%T Synthesis of new derivatives of pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine
%A Akaberi, Toktam
%A Rahimizadeh, Mohammad
%A Shiri, Ali
%J 21st Iranian Seminar of Organic Chemistry
%D 2014