Objectives: Domestic pigeons are used for thousands of years in Iran to carry brief written messages, sports tournaments and kept as an avian pet and as food for protein supply, along with human society and its use has spread. Today, many patient pigeons such as tumor removal, orthopedic surgery, suturing bites or other injuries from predators... are referred to clinics that most of them require general anesthesia. The most appropriate choice of anesthetic technique is one of the most important issues in a successful surgery. This study aimed to assess the quality of anesthesia and recovery time, Isoflurane and Propofol anesthesia drugs in domestic pigeons. Materials & Methods: Twenty male and female pigeons from a similar breed anesthetized by Isoflurane and Propofol. Ten pigeons anesthetized by Isoflurane without any pre-anesthetic drugs and anesthesia lasted for 30 minutes. Another ten pigeons without pre-anesthetic drugs, received 14 mg/kg of Propofol (10%) was injected slowly with catheter (Gage 24) to induce anesthesia and 1.33 mg/kg/min of Propofol for keeping the anesthesia and anesthesia lasted for 30 minutes. Temperature, heart rate, respiratory rate and saturation of peripheral oxygen (SPO2) were recorded in all three phases, before induction of anesthesia, after induction of anesthesia in minutes 1, 3, 5, 10, 15, 20, 25, 30 and after recovery time in both groups. Results & Conclusion: To compare the two groups studied parameters during the study period, the Independent samples T-test and to investigate changes in these parameters between the different measurements in each group, the Repeated measure ANOVA test was used, and values of P<0.05 was considered significant. In the present study, it was shown that the pigeons were anesthetized with Isoflurane, have a clear and fast anesthesia. But the pigeons were anesthetized with Propofol, have an irregular induction that not uniform for all pigeons and Propofol has a narrow margin of safety in pigeons. But overall Isoflurane anesthesia for pigeons is a better option.

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