Asian Pacific Journal of Cancer Prevention, ( ISI ), Volume (15), No (5), Year (2014-4) , Pages (2123-2128)

Title : ( Ferutinin, an Apoptosis Inducing Terpenoid from Ferula ovina )

Authors: Maryam Moghaddam Matin , Hossein Nakhaeizadeh , Ahmad Reza Bahrami , Mehrdad Iranshahi , nahid arghiani , Fatemeh Behnam Rassouli ,

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A current hurdle in cancer management is the intrinsic or acquired resistance of cancer cells to chemical agents that restricts the efficacy of therapeutic strategies . Accordingly, there is an increasing desire to discover new natural compounds with selective toxicity to combat malignancies.In present study,the cytotoxic and apoptosis-inducing activities of ferutinin, a terpenoid derivative from Ferula ovina , were investigated on human breast (MCF7) and bladder (TCC) cancer cells as well as normal fibroblasts(HFF3).The toxicity and DNA damage inducing effects of ferutinin were studied by MTT and comet assays, DAPI and PI staining and DNA laddering.The IC 50 values of ferutinin were identified and compared with routine prescribed drugs, doxorubicin and vincristine, by MTT test. Alkaline comet assay and DAPI staining revealed DNA damage due to ferutinin, which was significantly (p<0.001) higher in MCF7 and TCC than HFF3 cells.Apoptosis induction was evidenced by PI staining and DNA laddering. Our results suggest that ferutinin could be considered as an effective anticancer agent for future in vivo and clinical experiments

Keywords

, Anticancer , ferutinin , apoptosis , Ferula
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@article{paperid:1040921,
author = {Moghaddam Matin, Maryam and Nakhaeizadeh, Hossein and Bahrami, Ahmad Reza and Mehrdad Iranshahi and Arghiani, Nahid and Behnam Rassouli, Fatemeh},
title = {Ferutinin, an Apoptosis Inducing Terpenoid from Ferula ovina},
journal = {Asian Pacific Journal of Cancer Prevention},
year = {2014},
volume = {15},
number = {5},
month = {April},
issn = {1513-7368},
pages = {2123--2128},
numpages = {5},
keywords = {Anticancer - ferutinin - apoptosis - Ferula ovina},
}

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%0 Journal Article
%T Ferutinin, an Apoptosis Inducing Terpenoid from Ferula ovina
%A Moghaddam Matin, Maryam
%A Nakhaeizadeh, Hossein
%A Bahrami, Ahmad Reza
%A Mehrdad Iranshahi
%A Arghiani, Nahid
%A Behnam Rassouli, Fatemeh
%J Asian Pacific Journal of Cancer Prevention
%@ 1513-7368
%D 2014

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