This study investigates the ability of functionalized multi-walled carbon nanotubes (MWCNTs) for enantio separation of metoprolol chiral forms. 2Hydroxypropyl-β-cyclodextrin (2HP-β-CD) has been applied as a chiral selector to functionalize CNTs. The modified multi-walled CNT samples are characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The results of analyses show that CNTs are successfully cross-linked with 2HP- β-CD. To evaluate the enantio separation property of the products, the separation of metoprolol chiral forms on the initial and final products is examined. Further, UV visible spectroscopy and polarimeter analyses are used for characterization. The results indicate that MWCNT does not have any intrinsic enantio separation ability, though its selectivity for enantio separation can be enhanced by cross-linking it to 2HP-β-CD. Moreover, the optimal mass of adsorbent as well as optimal mass of functional groups is estimated to achieve maximum enantio separation efficiency. Results indicate that applying high amounts of 2HP-β-CD to CNTs functionalization decreases the cross-linking efficiency, which consequently reduce enantio separation efficiency

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